Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals
K. M. Braun, L. A. Haddock, C. M. Crooks, G. L. Barry, J. Lalli, G. Neumann, T. Watanabe, M. Imai, S. Yamayoshi, M. Ito, Y. Kawaoka, T. C. Friedrich
This study shows that H7N9 avian influenza viruses face strong evolutionary constraints during mammalian transmission, making human adaptation unlikely without rare, stochastic events.
bioRxiv · Apr 12, 2022Microbiology