N. Schultz-Darken

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

A novel vaccine targeting the viral protease cleavage sites protects Mauritian cynomolgus macaques against vaginal SIVmac251 infection

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

Long-term protection of rhesus macaques from Zika virus reinfection

This study shows that rhesus macaques retain neutralizing antibodies against ZIKV for at least 27 months, protecting them from detectable plasma viremia upon rechallenge.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

This study compares ZIKV replication kinetics and tissue distribution in rhesus macaques infected via mosquito bite versus subcutaneous inoculation, finding delayed viral peak and restricted tissue distribution in mosquito-infected animals.

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.