E. Peterson

Antagonizing the SAMD9 pathway is key to myxoma virus host shut-off and immune evasion.

This study characterizes the infection defect of a myxoma virus mutant lacking M062R, showing it fails to suppress host protein synthesis and activates antiviral responses through SAMD9 pathway activation.

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

The role of bacterial size, shape and surface in macrophage engulfment of uropathogenic E. coli cells

This study investigates how bacterial size, shape, surface, and environment affect macrophage engulfment of UPEC filaments, finding that multiple factors contribute to evasion.

A metagenomic investigation of spatial and temporal changes in sewage microbiomes across a university campus

This study investigates spatiotemporal changes in sewage microbiomes across a university campus using shotgun metagenomics, revealing dynamic patterns and environmental influences.

Mycobacterium abscessus biofilms produce an ECM and have a distinct mycolic acid profile

This study characterizes the extracellular matrix and mycolic acid profile of Mycobacterium abscessus biofilms, revealing molecular changes linked to antibiotic resistance.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed

The paper tracks expansion of HPV-specific T cells in blood and cervix after a therapeutic vaccine, using bulk and single-cell sequencing.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

This study compares ZIKV replication kinetics and tissue distribution in rhesus macaques infected via mosquito bite versus subcutaneous inoculation, finding delayed viral peak and restricted tissue distribution in mosquito-infected animals.

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.