M. Ito

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

Alterations of genomic imprinting appear during the reprogramming of adult neural stem cells

The paper analyzes genomic imprinting changes during reprogramming of adult neural stem cells into iPSCs, identifying transcriptome and methylation alterations linked to pluripotency and epigenetic quality.

Characterization of carotenoid-producing Muricauda sp. strains isolated from the reef-building coral Galaxea fascicularis and subtropical seawater

This study characterizes two Muricauda sp. strains isolated from coral and seawater, showing they produce carotenoids that may protect zooxanthellae from environmental stress.

Convolutional neural network model detected lasting behavioral changes in mouse with kanamycin-induced unilateral inner ear dysfunction

The paper uses a convolutional neural network to detect lasting behavioral changes in mice with unilateral inner ear dysfunction induced by kanamycin.

Characterization of an EG.5.1 clinical isolate in vitro and in vivo

This study characterizes the in vitro and in vivo properties of the EG.5.1 SARS-CoV-2 variant, showing increased transmissibility and altered antigenicity compared to XBB.1.5.

Extensive Copy Number Variation Explains Genome Size Variation in the Unicellular Zygnematophycean Alga, Closterium peracerosum-strigosum-littorale Complex

This study identifies genome size variation in the alga Closterium psl. complex as primarily due to copy number variation, with nonrandom distribution of CNV across gene functions.

The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development

The paper shows that E2Fs and RBR are essential for quiescence in plant development, with E2Fs specifically controlling both G1-S and G2-M targets.

Can SARS-CoV-2 transmit from a dead body?

This study investigates SARS-CoV-2 transmission from dead bodies using a hamster model, finding that transmission is possible but can be prevented by postmortem care and embalming.

Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

Targeted single-cell genomics reveals novel host adaptation strategies of the symbiotic bacteria Endozoicomonas in Acropora tenuis coral

This study uses single-cell genomics to analyze Endozoicomonas bacteria in Acropora tenuis corals, revealing host-adaptive genes that may enhance coral stress tolerance.

Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals

This study shows that H7N9 avian influenza viruses face strong evolutionary constraints during mammalian transmission, making human adaptation unlikely without rare, stochastic events.

Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study

This study develops a high-resolution melting assay to distinguish SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using mutation patterns in the spike protein with 100% sensitivity and >97.5% specificity.

A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

This study identifies a transcriptional network involving SCL28 and AtSMOS1 that regulates cell size and number in Arabidopsis by controlling G2 phase transitions through CDK inhibitors.

Highly-Neutralizing COVID-19-Convalescent-Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters.

This study shows that highly-neutralizing COVID-19 convalescent plasmas significantly reduce SARS-CoV-2 viral titers and lung lesions in Syrian hamsters compared to moderately neutralizing plasmas.

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

Ultra-small cells and DPANN genome unveiled inside an extinct vent chimney

The paper identifies ultra-small cells in an extinct hydrothermal vent chimney, associated with Pacearchaeota, using genome-resolved metagenomics and nanocrystal analysis.

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

Reduction of Short-Chain Fatty Acid-Producing Gut Microbiota Leads to Transition from Rapid-Eye-Movement Sleep Behavior Disorder to Parkinson's Disease

The paper analyzes gut microbiota in RBD and PD patients, finding increased Akkermansia and decreased SCFA-producing bacteria in PD, suggesting a link between gut dysbiosis and disease progression.

MafF is an antiviral host factor that suppresses transcription from Hepatitis B Virus core promoter

This study identifies MafF as an antiviral host factor that suppresses HBV core promoter transcription, contributing to host defense against HBV infection.

PCNA activates the MutLγ endonuclease to promote meiotic crossing over

This paper shows PCNA activates the MutLγ endonuclease to promote meiotic crossing over by facilitating strand-specific cleavage of Holliday junctions.

Mind the Outgroup: Influence of Taxon Sampling on Total-Evidence Dating of Pimpliform Parasitoid Wasps (Hymenoptera, Ichneumonidae)

This study shows that including more distant and poorly sampled outgroups in total-evidence dating makes age estimates older and less precise, and introduces an artefact called 'bare-branch attraction' that affects fossil placement.

Isolation of an archaeon at the prokaryote-eukaryote interface

The paper isolates an Asgard archaeon and proposes a symbiosis model for eukaryogenesis based on its morphology and metabolism.

Rhodosporidium toruloides: A new platform organism for conversion of lignocellulose into terpene biofuels and bioproducts

This paper demonstrates that Rhodosporidium toruloides can efficiently convert lignocellulosic hydrolysates into terpenes like bisabolene and amorphadiene, outperforming purified substrates in productivity.