A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue
B. J. Wadsworth, M. Leiwe, E. Minogue, P. P. Cunha, V. Engman, C. Brombach, C. Asvestis, S. K. Sah-Teli, E. Marklund, P. Karppinen, J. L. Ruas, H. Rundqvist, J. Lanner, R. S. Johnson
This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.
bioRxiv · Oct 16, 2023Physiology