Author

P. Karppinen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

P. P. Cunha· 2 shared R. S. Johnson· 2 shared S. K. Sah-Teli· 2 shared A. Quaranta· 1 shared B. J. Wadsworth· 1 shared B. Wadsworth· 1 shared C. Asvestis· 1 shared C. Brombach· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPhysiology

P. P. Cunha

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Author profile →

2 papers

Recent·Most cited

A 2-Hydroxybutyrate-mediated feedback loop regulates muscular fatigue

B. J. Wadsworth, M. Leiwe, E. Minogue, P. P. Cunha, V. Engman, C. Brombach, C. Asvestis, S. K. Sah-Teli, E. Marklund, P. Karppinen, J. L. Ruas, H. Rundqvist, J. Lanner, R. S. Johnson

This study shows that 2-hydroxybutyrate (2HB) produced during exercise inhibits branched-chain aminotransferases, leading to metabolic changes that enhance oxidative capacity.

bioRxiv · Oct 16, 2023Physiology

Glutarate regulates T cell function and metabolism

E. A. Minogue, P. P. Cunha, A. Quaranta, J. Zurita, S. K. Sah-Teli, B. Wadsworth, R. Hughes, G. Grice, P. Velica, D. Bargiela, L. Barbieri, C. Wheelock, J. A. Nathan, P. Karppinen, I. P. Foskolou, R. S. Johnson

This study shows that glutarate regulates T cell function and metabolism by inhibiting KGDDs and modifying the pyruvate dehydrogenase E2 subunit, enhancing CD8+ T cell cytotoxicity and reducing tumor growth.

bioRxiv · Oct 20, 2022 · PreprintImmunology