Cancer BiologybioRxiv
Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs
T. V. Cornforth, N. A. Moyo, S. Cole…·J. Dukes
The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.
DOI 10.3389/fonc.2024.1419528