E. Lam

The genomes and epigenomes of aquatic plants (Lemnaceae) promote triploid hybridization and clonal reproduction

This paper presents genome and epigenome analyses of Lemnaceae plants, identifying genes related to clonal reproduction and CO2 sequestration, and highlights their potential for biotechnology.

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

Optimization of molecular methods for detection and quantification of specific duckweed-bacteria interactions

This study develops molecular methods to detect and quantify specific duckweed-bacteria interactions by optimizing protocols and creating strain-specific primers for accurate differentiation.

Engineering and characterization of carbohydrate-binding modules to enable real-time imaging of cellulose fibrils biosynthesis in plant protoplasts

This study engineers and characterizes tandem carbohydrate-binding modules (CBMs) to enable real-time imaging of cellulose fibril biosynthesis in Arabidopsis protoplasts.

Genomics of turions from the Greater Duckweed reveal its pathways for dormancy and reemergence strategy

This study analyzes the transcriptome and epigenome of turions from Greater Duckweed to identify molecular pathways involved in dormancy and reemergence.

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Enhanced retinoid response by a combination of the vitamin A ester retinyl propionate with niacinamide and a flavonoid containing Ceratonia siliqua extract in retinoid responsive in vitro models.

The paper evaluates if combining retinyl propionate with niacinamide and a Ceratonia siliqua extract enhances retinoid activity in vitro, finding increased gene expression and reporter activation.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Genome and time-of-day transcriptome of Wolffia australiana link morphological extreme minimization with un-gated plant growth

This study analyzes the genome and time-of-day transcriptome of Wolffia australiana to link its extreme morphological minimization with reduced circadian regulation and continuous growth.

Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

Structural Basis for Ca2+-Dependent Activation of a Plant Metacaspase

This study determines the crystal structure of AtMC4, revealing how Ca2+ activates plant metacaspase through linker domain cleavage and substrate access.

Perinatal Programming of Mucosal Stromal Cell Identity by the Lymphotoxin Pathway Regulates Mucosal Immune Responses in the Adult

This study shows that in utero Lymphotoxin-beta receptor signaling programs mesenteric lymph node stromal cells to support adult IgA responses by influencing antibody class switch and IgA+ cell generation.