Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells
M. Hu, R. Liu, N. Castro, L. Loza Sanchez, J. Learn, R. Huang, K. S. Lam, K. L. Carraway
This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.
bioRxiv · May 25, 2023 · PreprintPharmacology & Toxicology