Pharmacology & ToxicologybioRxivPreprint
Structure-Activity Relationship Study Identifies a Novel Lipophilic Amiloride Derivative that Efficiently Kills Chemoresistant Breast Cancer Cells
M. Hu, R. Liu, N. Castro…·K. L. Carraway
This study identifies a novel amiloride derivative, LLC1, that shows potent cytotoxicity against chemoresistant breast cancer cell lines but limited efficacy in a metastatic mouse model.