Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis
Y. Lai, M. Tuvim, J. Leitz, J. J. Peters, R. Pfuetzner, L. Esquivies, Q. Zhou, B. Czako, J. Cross, P. Jones, B. Dickey, A. T. Brunger
The paper screens hydrocarbon-stapled peptides targeting the SNARE-Syt1 primary interface to inhibit Ca2+-triggered exocytosis and mucus hypersecretion.
bioRxiv · Mar 21, 2022Pharmacology & Toxicology