P. Jones

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Investigating the translational value of Periprosthetic Joint Infection (PJI) models to determine the risk and severity of Staphylococcal biofilms.

This study evaluates preclinical models to assess the risk and severity of Staphylococcal biofilms in periprosthetic joint infections and their antibiotic susceptibility.

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

Intact and Degenerate Diguanylate Cyclases regulate Shigella Cyclic di-GMP

This study examines the role of intact and degenerate DGCs in Shigella c-di-GMP synthesis and pathogenesis, finding that some degenerate DGCs still produce c-di-GMP despite mutations.

Plant inositol transport influences bacterial colonization phenotypes

The paper investigates how plant inositol transport affects bacterial colonization by combining metatranscriptomic data and genetic experiments in Arabidopsis.

A new concept in antiviral drug design yields a potent influenza inhibitor

This paper introduces a new antiviral drug design approach that alters the virion surface microenvironment to block influenza virus entry, showing potent in vitro and in vivo activity.

Screening of hydrocarbon-stapled peptides for inhibition of calcium-triggered exocytosis

The paper screens hydrocarbon-stapled peptides targeting the SNARE-Syt1 primary interface to inhibit Ca2+-triggered exocytosis and mucus hypersecretion.

Genomic signatures of isolation, hybridization, and selection during speciation of island finches

This study examines genomic signatures of isolation, hybridization, and selection in sympatric island finches, revealing complex speciation dynamics involving genetic drift, introgression, and natural selection.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

Biotechnological exploitation of Saccharomyces jurei and its hybrids in craft beer fermentation uncovers new aroma combinations.

This study creates non-GMO hybrids between Saccharomyces jurei and ale yeasts to develop craft beer strains with improved fermentation and complex flavor profiles.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studies

The paper analyzes missense mutations in NOTCH1 and NOTCH2 in human oesophageal epithelium to infer structure-function relationships through in vivo selection pressures.

Distributed Biomanufacturing of Liquefied Petroleum Gas

This paper demonstrates the production of bio-LPG from waste volatile fatty acids using engineered microbes, offering a sustainable alternative to fossil fuels.

Differences in resources use lead to coexistence of seed-transmitted microbial populations

The paper investigates how resource use differences affect the coexistence of microbial populations on radish seeds, identifying potential native bacteria that could limit pathogen transmission.