J. Lima

Epithelial-mesenchymal plasticity induced by discontinuous exposure to TGFβ1 promotes tumour growth

The paper shows that discontinuous TGFβ1 exposure induces EMT/MET transitions in EpH4 cells, leading to RE-cells with molecular and functional heterogeneity that promotes tumour growth.

Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane

Trackosome tracks centrosomes and reconstructs nuclear and cellular membranes from live-imaging data, revealing correlations between centrosome movements and nuclear envelope oscillations.

Population structure determined by comparative amplicon gene sequencing in biofilm and planktonic bacterial communities from pesticide-contaminated water

The paper uses 16S rRNA gene sequencing to compare bacterial population structure in planktonic and biofilm communities from pesticide-contaminated water, finding greater diversity in biofilms due to adaptation to stressful conditions.

APOBEC-mediated DNA alterations: a possible new mechanism of carcinogenesis in EBV-positive gastric cancer

The paper identifies a positive correlation between APOBEC3 mRNA-expression and APOBEC-mutation signature in EBV+ gastric cancer, suggesting APOBEC3 upregulation may increase mutation load.

Skin microbiome modulation induced by probiotic solutions

The paper demonstrates that applying donor microbiome mixtures can alter recipient skin microbiome composition, with engraftment levels depending on donor-recipient compatibility and bacterial load.