A. L. Szymczak-Workman

The paper shows that Tim-3 expression in Treg cells drives them to an effector-like state with enhanced suppressive activity, promoting tumor growth.

This study identifies Akt and MAPK signaling as essential for Tim-3 co-stimulatory activity and shows that Tim-3 localization to the immune synapse is critical for its function.

This study shows NEMO is recruited into TCR microclusters via polyubiquitin recognition domains, requiring Lck and ZAP-70 but not LAT or SLP-76.

This study identifies TrIP as a negative regulator of T cell activation by inhibiting PI3K, showing its role in immune response and potential as a therapeutic target.

This study shows Tim-3 promotes short-term effector T cells and restricts memory precursors during acute infection, but is not required for T cell exhaustion.