Structure of EPCR in a non-canonical conformation
J. Lopez-Sagaseta, E. Erausquin Arrondo, A. Rodriguez Fernandez
This study identifies a non-canonical conformation of EPCR through X-ray diffraction and confirms its impact on protein C binding.
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3 papers
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J. Lopez-Sagaseta, E. Erausquin Arrondo, A. Rodriguez Fernandez
This study identifies a non-canonical conformation of EPCR through X-ray diffraction and confirms its impact on protein C binding.
E. Erausquin, J. Lopez-Sagaseta
The paper identifies a single amino acid substitution in SARS-CoV-2 spike that enhances binding to human ACE2, with structural evidence supporting the increased affinity.
E. E. Arrondo, M. Moran-Garrido, J. Saiz…·J. Lopez-Sagaseta
The paper identifies a novel β T-cell subpopulation recognizing EPCR, showing lipid-independent self-recognition and novel EPCR ligands.