C. Barbas

Allergic inflammation triggers dyslipidemia via IgG signalling

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

Pentose Phosphate Pathway Inhibition activates Macrophages towards phagocytic Lymphoma Cell Clearance

This study shows that inhibiting the pentose phosphate pathway enhances macrophage phagocytosis of lymphoma cells and improves survival in a mouse model.

Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responses

This study investigates the interaction between the molecular clock and kidney fibrosis in experimental models, finding that clock components influence inflammation and fibrosis, while fibrosis alters clock gene expression.

Metabolic snapshot of plasma samples reveals new pathways implicated in SARS-CoV-2 pathogenesis

The paper uses metabolomics to identify metabolic pathways associated with SARS-CoV-2 susceptibility and COVID-19 severity in plasma samples.

An evolutionarily ancient Fatty Acid Desaturase is required for the synthesis of hexadecatrienoic acid, which is the main source of the bioactive jasmonate in Marchantia polymorpha

This study identifies MpFAD5 in Marchantia polymorpha as essential for synthesizing hexadecatrienoic acid, the main source of bioactive jasmonate, and shows that dn-OPDA levels are nearly depleted in mutants.

A novel α/β T-cell subpopulation defined by recognition of EPCR

The paper identifies a novel β T-cell subpopulation recognizing EPCR, showing lipid-independent self-recognition and novel EPCR ligands.

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

This study shows that overexpressing Cpt1a in renal tubular epithelial cells reduces fibrosis by restoring mitochondrial function and bioenergetics in CKD models and human patients.