MicrobiologybioRxiv
The TIR-domain containing effectors BtpA and BtpB from Brucella abortus block energy metabolism
J. M. Coronas-Serna, A. Louche, M. Rodriguez-Escudero…·S. P. Salcedo
This study shows BtpA and BtpB from Brucella abortus reduce host cell NAD+ levels by acting as NAD+ hydrolases, impairing energy metabolism and immune responses.