Author

J. M. Hogle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. J. Macadam· 1 shared A. Martyna· 1 shared A. Tedcastle· 1 shared D. J. Filman· 1 shared D. Rowlands· 1 shared E. Groppelli· 1 shared E. L. Hesketh· 1 shared E. Pegg· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. J. Macadam

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2 papers

Recent·Most cited

Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate.

N. J. Kingston, J. S. Snowden, A. Martyna, M. Shegdar, K. Grehan, A. Tedcastle, E. Pegg, H. Fox, A. J. Macadam, J. Martin, J. M. Hogle, D. Rowlands, N. J. Stonehouse

This study produces antigenically stable EVA71 virus-like particles in Pichia pastoris, showing they retain native antigenic conformation and elicit neutralising antibodies comparable to inactivated virus vaccines.

bioRxiv · Jan 30, 2023 · PreprintImmunology

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.

P. N. M. Shah, D. J. Filman, K. S. Karunatilaka, E. L. Hesketh, E. Groppelli, M. Strauss, J. M. Hogle

The paper identifies two distinct conformational states of the 135S poliovirus particle using cryo-EM, showing that VP1 N-terminus externalization and VP4 retention vary between states.

PLOS Pathogens · Sep 30, 2020Peer-reviewedBiophysics