Author

D. J. Filman

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

E. Groppelli· 1 shared E. L. Hesketh· 1 shared J. M. Hogle· 1 shared K. S. Karunatilaka· 1 shared M. Strauss· 1 shared P. N. M. Shah· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiophysics

E. Groppelli

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1 paper

Recent·Most cited

BiophysicsPLOS PathogensPeer-reviewedSep 30, 2020

Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate.

P. N. M. Shah, D. J. Filman, K. S. Karunatilaka…·J. M. Hogle

The paper identifies two distinct conformational states of the 135S poliovirus particle using cryo-EM, showing that VP1 N-terminus externalization and VP4 retention vary between states.

DOI 10.1371/journal.ppat.1008920

cryo-EMexperimental assay

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