Author

J. M. Loo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

N. Yamaguchi· 2 shared S. F. Tavazoie· 2 shared A. Barlas· 1 shared A. Cercek· 1 shared A. E. Hendifar· 1 shared A. J. McRee· 1 shared A. Nguyen· 1 shared C. Andreu-Agullo· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

N. Yamaguchi

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2 papers

Recent·Most cited

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

I. Kurth, N. Yamaguchi, C. Andreu-Agullo, H. S. Tian, S. Sridhar, S. Takeda, F. C. Gonsalves, J. M. Loo, A. Barlas, K. Manova-Todorova, R. Busby, J. C. Bendell, J. Strauss, M. Fakih, A. J. McRee, , S. F. Tavazoie

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

bioRxiv · Apr 26, 2021Cancer Biology

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia

N. Yamaguchi, E. Weinberg, A. Nguyen, M. V. Liberti, H. Goodarzi, Y. Y. Janjigian, P. B. Paty, L. B. Saltz, T. P. Kingham, J. M. Loo, E. d. Stanchina, S. F. Tavazoie

This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.

bioRxiv · Nov 7, 2019Cancer Biology