Author

A. Barlas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

W. R. Karthaus· 3 shared A. Cercek· 2 shared A. Gopalan· 2 shared A. Jungbluth· 2 shared C. L. Sawyers· 2 shared D. W. Goodrich· 2 shared H. I. Scher· 2 shared I. Linkov· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

W. R. Karthaus

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Author profile →

5 papers

Recent·Most cited

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

S. Zaidi, J. Park, J. M. Chan, M. Roudier, J. L. Zhao, A. Gopalan, K. M. Wadosky, R. A. Patel, E. Sayar, W. R. Karthaus, D. H. Kates, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, , C. Sawyers

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

s. gadal, J. A. Boyer, S. F. Roy, N. A. Outmezguine, M. Sharma, H. Li, N. Fan, E. Chan, Y. Romin, A. Barlas, Q. Chang, P. Pancholi, N. M. Timaul, M. Overholtzer, R. Yaeger, , N. Rosen

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

bioRxiv · Nov 21, 2023 · PreprintCancer Biology

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

I. Kurth, N. Yamaguchi, C. Andreu-Agullo, H. S. Tian, S. Sridhar, S. Takeda, F. C. Gonsalves, J. M. Loo, A. Barlas, K. Manova-Todorova, R. Busby, J. C. Bendell, J. Strauss, M. Fakih, A. J. McRee, , S. F. Tavazoie

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

bioRxiv · Apr 26, 2021Cancer Biology

A rectal cancer model establishes a platform to study individual responses to chemoradiation

K. Ganesh, C. Wu, K. P. O'Rourke, M. Adileh, B. C. Szeglin, I. Wasserman, M. R. Marco, M. Shady, Y. Zheng, W. R. Karthaus, H. H. Won, S.-H. Choi, R. A. Pelossof, A. Barlas, E. Pappou, , J. J. Smith

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

bioRxiv · May 22, 2019 · PreprintCancer Biology