N. Yamaguchi

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

The paper analyzes genomic data from extinct Cape lions to show they were not genetically distinct from other African lions, challenging earlier claims of their uniqueness.

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

This study analyzes mitochondrial genomes of ancient brown bears and lions to show synchronous dispersal and extinction events across the Bering Land Bridge during the Pleistocene.

The paper shows that JMJ proteins remove repressive histone marks in Arabidopsis, enabling epigenetic memory of heat exposure to improve heat tolerance.

The paper shows TFL1 and FT antagonistically regulate floral fate through chromatin recruitment and competition, with LFY as a key target gene.

This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.