S. Sridhar

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

The landscape of extrachromosomal circular DNA in medulloblastoma

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of Salmonella Typhimurium

This study shows that inhibitory concentrations of ciprofloxacin induce adaptive responses in Salmonella Typhimurium that enhance intracellular survival and replication.

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

Diversification of Transcription Factor NF-κB in Protists

This paper functionally characterizes NF-κB in protists, showing its structural and regulatory diversity and evolutionary origins outside of metazoans.

High-content imaging to phenotype antimicrobial effects on individual bacteria at scale

This paper develops a high-throughput high-content imaging method to phenotype bacterial responses to antimicrobials, revealing morphological differences between susceptible and resistant isolates.

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassembly

This study identifies a novel role of Sgo1 in facilitating spindle disassembly and maintaining the spindle assembly checkpoint in Candida albicans.

Molecular Typing of Human Respiratory Adenoviruses with Universal PCR and Sequencing Primers for Three Major Capsid Genes: Penton base, Hexon, and Fiber

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

Identification of bridgin, an unconventional linker, connects the outer kinetochore to centromeric chromatin

The paper identifies bridgin, a new linker protein in fungi, that connects the outer kinetochore to centromeric chromatin, differing from known linker proteins.