J. Strauss

Deep Learning Model Imputes Missing Stains in Multiplex Images

The paper introduces a deep learning model, MAXIM, to impute missing protein markers in multiplex images, improving efficiency in staining and imaging processes.

Additively manufactured multiplexed electrochemical device (AMMED) for portable sample-to-answer detection

This paper introduces AMMED, a portable electrochemical device for rapid, multiplexed biomarker detection in blood and saliva, demonstrating its ability to detect SARS-CoV-2 spike protein with high sensitivity and selectivity.

Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

The paper investigates the substrate recognition mechanism of the bacterial POT DtpB using structural and biochemical analyses, revealing that compact hydrophobic peptides are optimal binders.

An update on eukaryotic viruses revived from ancient permafrost

The paper reports the isolation and characterization of 13 new viruses from ancient permafrost samples, highlighting their potential to challenge assumptions about the rarity of revived viruses.

Functional and structural asymmetry suggest a unifying principle for catalysis in integral membrane-bound pyrophosphatases

This study presents the first structure of a K+-independent M-PPase and shows asymmetric and time-dependent substrate binding, proposing a unified model for ion pumping and energy coupling in M-PPases.

Anaerobic methane oxidizing archaea offset sediment methane concentrations in Arctic thermokarst lagoons

The paper examines methane cycling in Arctic thermokarst lagoons and finds that sulfate-driven anaerobic methane oxidation reduces sediment methane concentrations.

Prediction of cancer treatment response from histopathology images through imputed transcriptomics

ENLIGHT-DeepPT predicts cancer treatment response from H&E slides by first imputing transcriptomics and then using that data to predict response across multiple therapies and cancer types.

Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces - Aspergillus interaction.

The paper identifies polaramycin B as the signaling molecule, not physical contact, that triggers metabolic rewiring in the Streptomyces-Aspergillus interaction by inducing ORS production and altering gene expression.

Pfcerli2, a duplicated gene in the malaria parasite Plasmodium falciparum essential for invasion of erythrocytes as revealed by phylogenetic and cell biological analysis.

This study identifies PfCERLI2 as an essential protein for merozoite invasion in Plasmodium falciparum through phylogenetic and cell biological analysis.

Global analysis of putative phospholipases in the malaria parasite Plasmodium falciparum reveals critical factors for parasite proliferation

The paper identifies essential phospholipases in Plasmodium falciparum, showing PF3D7_1013500 is critical for parasite maturation and PF3D7_1358000 is vital for mitochondrial function and growth.

Therapeutic targeting of SLC6A8 creatine transporter inhibits KRAS mutant and wildtype colon cancer and modulates human creatine levels

RGX-202 inhibits CRC growth by targeting SLC6A8 creatine transporter, reduces creatine and ATP levels, and shows efficacy in multiple tumor models and human trials.

High prevalence and diversity of beta-lactamase-encoding bacteria in cryosoils and ancient permafrost

This study identifies a high prevalence of beta-lactamase-encoding bacteria in Arctic and subarctic soils and permafrost, suggesting global warming could mobilize ancient DNA and contribute to antibiotic resistance.

Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite Plasmodium falciparum

This study identifies new IMC and apical annuli proteins in Plasmodium falciparum using BioID proteomics and validates their localization.

Stability of extemporaneously compounded amiloride nasal spray

This study evaluates the stability of an extemporaneously compounded amiloride nasal spray over 7 days at room temperature, showing it remains physically, chemically, and microbiologically stable.

Activation of silent secondary metabolite gene clusters by nucleosome map-guided positioning of the synthetic transcription factor VPR-dCas9

This paper introduces a synthetic transcription factor system to activate silent secondary metabolite gene clusters in Aspergillus nidulans by positioning VPR-dCas9 using nucleosome maps.

Structure-based identification and functional characterization of an essential lipocalin in the malaria parasite Plasmodium falciparum

This study identifies and characterizes PfLCN, a lipocalin in Plasmodium falciparum, showing its role in oxidative stress response and parasite survival.

A New European Species of The Opportunistic Pathogenic Genus Saksenaea - S. dorisiae Sp. Nov.

The paper describes a new species of the opportunistic pathogenic genus Saksenaea, S. dorisiae, isolated from a Serbian water sample and characterized by phylogenetic and morphological analyses.