Cancer BiologyBioorganic & Medicinal ChemistryPeer-reviewed
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors
J. M. Rohde, K. R. Brimacombe, L. Liu…·M. B. Boxer
The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.
DOI 10.1016/j.bmc.2018.02.016