Author

A. Jadhav

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

M. D. Hall· 2 shared M. Shen· 2 shared O. W. Lee· 2 shared P. Shah· 2 shared X. Xu· 2 shared A. Glukhova· 1 shared A. McIver· 1 shared A. Schwendeman· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

M. D. Hall

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Author profile →

4 papers

Recent·Most cited

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

H. Zhu, O. W. Lee, P. Shah, A. Jadhav, X. Xu, S. Patnaik, M. Shen, M. D. Hall

This study identifies small molecule activators of human fumarate hydratase through quantitative high-throughput screening, revealing compounds that enhance FH activity without being substrates or redox agents.

bioRxiv · Jul 2, 2019Biochemistry

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

K. A. Manthei, S.-M. Yang, B. Baljinnyam, L. Chang, A. Glukhova, W. Yuan, L. A. Freeman, D. J. Maloney, A. Schwendeman, A. T. Remaley, A. Jadhav, J. J. G. Tesmer

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

bioRxiv · Sep 20, 2018Biochemistry

Chemical control of a CRISPR-Cas9 acetyltransferase

J. H. Shrimp, C. Grose, S. R. T. Widmeyer, A. Jadhav, J. L. Meier

The paper develops a CRISPR-Cas9-based tool to study acetylation-dependent gene expression and identifies small molecule inhibitors of p300 activity.

bioRxiv · Aug 16, 2017Biochemistry

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

D. J. Urban, N. J. Martinez, M. I. Davis, K. R. Brimacombe, D. M. Cheff, T. D. Lee, M. J. Henderson, S. A. Titus, R. Pragani, J. M. Rohde, Y. Wang, S. Karavadhi, P. Shah, O. W. Lee, A. Wang, , M. D. Hall

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.

bioRxiv · Apr 7, 2017Cancer Biology