ImmunologybioRxiv
Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C
M. J. W. Sim, S. A. Malaker, A. Khan…·R. J. Boyton
This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.
DOI 10.3389/fimmu.2017.00193