Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development
C. P. Couturier, S. Ayyadhury, P. U. Le, J. Monlong, G. Riva, R. Allache, S. Baig, X. Yan, M. Bourgey, C. Lee, Y. C. D. Wang, V. W. Yong, M.-C. Guiot, B. Misic, J. Antel, , K. Petrecca
The paper uses single-cell RNA-seq to show glioblastoma recapitulates normal brain development, identifying a conserved trilineage hierarchy with glial progenitor-like cells as the origin of cancer heterogeneity and therapeutic targets.
bioRxiv · Oct 22, 2018 · PreprintCancer Biology