Author

G. Bourque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Sinnett· 2 shared M. Caron· 2 shared A. Lemieux· 1 shared A. Pramatarova· 1 shared A. S. Pacis· 1 shared B. Misic· 1 shared C. Groza· 1 shared C. Lee· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

D. Sinnett

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

E. Elder, A. Lemieux, L.-M. Legault, M. Caron, V. Bertrand-Lehouillier, T. Dupas, N. J.-M. Raynal, G. Bourque, D. Sinnett, N. Gevry, S. McGraw

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

bioRxiv · May 7, 2024Cell Biology

Transposable elements are associated with the variable response to influenza infection

X. Chen, A. S. Pacis, K. A. Aracena, S. Gona, T. Kwan, C. Groza, Y. L. Lin, R. H. M. Sindeaux, V. Yotova, A. Pramatarova, M.-M. Simon, T. M. Pastinen, L. B. Barreiro, G. Bourque

The paper investigates the role of transposable elements in variable influenza infection responses by analyzing transcriptome and chromatin accessibility data from infected macrophages.

bioRxiv · May 10, 2022Immunology

Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity

M. Caron, P. St-Onge, T. Sontag, Y. C. Wang, C. Richer, I. Ragoussis, D. Sinnett, G. Bourque

This study analyzes single-cell transcriptomes of childhood leukemia patients to show that developmental state and ribosomal protein expression contribute to intra-individual heterogeneity.

bioRxiv · Jun 27, 2019Cancer Biology

Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development

C. P. Couturier, S. Ayyadhury, P. U. Le, J. Monlong, G. Riva, R. Allache, S. Baig, X. Yan, M. Bourgey, C. Lee, Y. C. D. Wang, V. W. Yong, M.-C. Guiot, B. Misic, J. Antel, , K. Petrecca

The paper uses single-cell RNA-seq to show glioblastoma recapitulates normal brain development, identifying a conserved trilineage hierarchy with glial progenitor-like cells as the origin of cancer heterogeneity and therapeutic targets.

bioRxiv · Oct 22, 2018 · PreprintCancer Biology