EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes
Bin Wan, P. Du, A. Ferrari, A. Saberi, A. John, J. Yan, X. Liu, J. Y. Hansen, Z.-Q. Liu, S.-J. Hong, F. Carruzzo, M. Kaliuzhna, T. Geffen, T. Katthagen, B. Misic, , M. Kirschner
The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.
bioRxiv · Nov 2, 2026 · PreprintNeuroscience