PathologybioRxiv
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells
J. Wang, H. Filippakis, T. Hougard…·H. C. Lam
This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.
DOI 10.1073/pnas.2101268118