H. Du

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

Urea amidolyase as the enzyme for urea utilization in algae: functional display in Chlamydomonas reinhardtii and evolution in algae

This study identifies urea amidolyase (UAD) as the key enzyme for urea utilization in algae, showing its functional importance and evolutionary distribution in Chlamydomonas reinhardtii.

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

A general platform for targeting MHC-II antigens via a single loop

This paper introduces TRACeR-II, a platform for developing MHC-II binders using a single loop, demonstrating its versatility and applicability to SARS-CoV-2 peptides.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

Histone deacetylase 3 plays a critical role in hypertension-induced kidney inflammation and fibrosis

This study shows that myeloid HDAC3 deficiency protects against angiotensin II-induced kidney inflammation and fibrosis in mice.

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma Pathogenesis

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

rcsB enhances drug resistance of Klebsiella pneumoniae ATCC43816 by regulating the formation of its capsule

The paper investigates drug resistance in Klebsiella pneumoniae, finding that rcsB regulates capsule formation, which affects drug resistance.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

Diversity and ecological function of urease-producing bacteria in the cultivation environment of Gracilariopsis lemaneiformis

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Born with intronless ERF transcriptional factors: C4 photosynthesis inherits a legacy dating back 450 million years

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

The transcriptional regulator JAZ8 interacts with the C2 protein from geminiviruses and limits the viral infection in Arabidopsis

This study shows JAZ8 interacts with geminiviral C2 proteins and limits viral infection in Arabidopsis.

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

Subgenomic SARS-CoV-2 replicon and reporter replicon cell lines enable ultrahigh throughput antiviral screening and mechanistic studies with antivirals, viral mutations or host factors that affect COVID-19 replication

This paper develops SARS-CoV-2 replicon systems and cell lines for antiviral screening and mechanistic studies, enabling research at lower biosafety levels.

Disordered climate threatens short-distance migrants

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

Molecular basis and evolutionary cost of a novel phenotype of macrolides/lincosamides resistance in Staphylococcus haemolyticus

This study identifies a novel constitutive MLS resistance in S. haemolyticus and shows that ErmC deletion causes resistance while continuous ErmC expression imposes a growth cost.

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.

The female urinary microbiota in relation to the reproductive tract microbiota

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

Ceftazidime Is a Potential Drug to Inhibit SARS-CoV-2 Infection In Vitro by Blocking Spike Protein-ACE2 Interaction

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

Annexina2 as a target protein for chlorogenic acid in human lung cancer A549 cells

This study identifies annexin A2 as a target protein of chlorogenic acid in A549 cells, showing it inhibits tumor proliferation by suppressing NF-κB downstream anti-apoptotic genes.

Persistent cell proliferation signals correlates with increased glycolysis in tumor hypoxia microenvironment across cancer types

The paper identifies a 22-gene expression signature to measure glycolysis activity across 25 cancer types, showing its correlation with hypoxia, genomic instability, and tumor proliferation.