SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication
S. Halder, I. Torrecilla, M. Burkhalter, M. Popovic, J. Fielden, B. Vaz, J. Oehler, D. Pilger, D. Lessel, K. Wiseman, A. N. Singh, I. Vendrell, R. Fischer, M. Philipp, K. Ramadan
This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.
bioRxiv · Oct 31, 2018Cell Biology