Author

K. Ramadan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. N. Singh· 2 shared B. Vaz· 2 shared I. Torrecilla· 2 shared I. Vendrell· 2 shared M. Popovic· 2 shared P. Lascaux· 2 shared R. Fischer· 2 shared A. A. Ahmed· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. N. Singh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LARP1 regulates metabolism and mTORC1 activity in cancer

J. Chettle, Z. Dedeic, R. Fischer, I. Vendrell, L. Campo, A. Easton, M. Browne, J. Morris, H. Schwenzer, P. Lascaux, R. Gijsbers, E. Pires, D. J. Royston, D. J. P. Ferguson, A. Coosemans, , S. P. Blagden

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

The NUCKS1-SKP2-p21/p27 axis controls S phase entry

S. Hume, C. P. Grou, P. Lascaux, V. D'Angiolella, A. J. Legrand, K. Ramadan, G. L. Dianov

The paper identifies the NUCKS1-SKP2-p21/p27 axis as a checkpoint pathway regulating S phase entry by integrating mitogenic and DNA damage signals.

bioRxiv · Jun 29, 2021Cancer Biology

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

B. Vaz, A. Ruggiano, M. Popovic, G. Rodriguez-Berriguete, S. Kilgas, A. N. Singh, I. Torrecilla, G. Higgins, A. Kiltie, K. Ramadan

This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.

bioRxiv · Feb 14, 2020 · PreprintCell Biology

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

C. I. Wells, H. Al-Ali, D. M. Andrews, C. R. M. Asquith, A. D. Axtman, M. Chung, I. Dikic, D. Ebner, J. Elkins, P. Ettmayer, C. Fischer, M. Frederiksen, N. S. Gray, S. B. Hatch, S. Knapp, , D. H. Drewry

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

bioRxiv · Dec 22, 2019Cell Biology

SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

S. Halder, I. Torrecilla, M. Burkhalter, M. Popovic, J. Fielden, B. Vaz, J. Oehler, D. Pilger, D. Lessel, K. Wiseman, A. N. Singh, I. Vendrell, R. Fischer, M. Philipp, K. Ramadan

This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.

bioRxiv · Oct 31, 2018Cell Biology