The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet.
J. Hwang, J. Okada, L. Liu, J. E. Pessin, G. J. Schwartz, Y.-H. Jo
This study shows that parasympathetic cholinergic neurons innervating the liver prevent hepatic steatosis in mice on a high-fat diet by promoting browning of white adipose tissue and altering bile acid metabolism.
bioRxiv · Nov 3, 2023Physiology