A. Watanabe

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface

This paper identifies a class of human antibodies that bind a conserved HA head-stem interface epitope, offering broad protection against influenza A serotypes in mice.

Analysis of chronic host-aspergilloma interactions using a novel mouse model

This paper develops a novel mouse model of aspergilloma to study host-fungal interactions, revealing Th1/Th17 responses and angiogenesis induced by dead fungal hyphae.

Lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli: differential and interactive effects on novelty-induced hyperlocomotion, blood cytokine levels and TRL4-related processes

This study compares the effects of Porphyromonas gingivalis and Escherichia coli lipopolysaccharides on mouse behavior, cytokine levels, and TLR4 signaling, finding differential impacts on locomotion and cytokine responses.

Bacterial composition changes in canine plaque over periodontal disease severity and daily care practices

This study examines how bacterial composition in canine plaque changes with periodontal disease severity and daily care practices, finding increased Porphyromonas and decreased Conchiformibius with disease progression and improved outcomes with dental gel brushing.

AI in Paleontology

This paper reviews AI applications in paleontology, highlighting a gap between paleontological AI and mainstream AI studies, and discusses future directions for integrating AI into paleontological research.

A class of antibodies that overcome a steric barrier to cross-group neutralization of influenza viruses

This paper identifies a class of antibodies that neutralize both H1 and H3 influenza viruses by overcoming a steric barrier at the HA RBS.

An epitope-enriched immunogen increases site targeting in germinal centers

This study shows that an epitope-enriched immunogen preferentially expands RBS-directed antibody responses compared to non-enriched immunogens.

The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

This paper reports the structure and function of the photosystem I supercomplex in Ostreococcus tauri, showing it assembles with light-harvesting complexes and exhibits reversible photoacclimation.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

The Administration Effect of Lactic Acid Bacteria Reducing Environmental Alkyl and Fatty Acid Hydroperoxides on Piglets in the Absence of Antimicrobial Agents and in the Presence of Iron

This study shows that administering LpP1-2 to prepartum sows and piglets improves growth and reduces oxidative stress markers, with benefits persisting into early rearing.

Novel neuroanatomical integration and scaling define avian brain shape evolution and development

This study examines brain shape evolution in birds and their dinosaur relatives, finding that brain morphology evolved through both integrated and mosaic processes, with distinct scaling relationships in different regions.

Arf GTPase-Activating proteins SMAP1 and AGFG2 regulate the size of Weibel-Palade bodies and exocytosis of von Willebrand factor

This study identifies SMAP1 and AGFG2 as ArfGAPs regulating Weibel-Palade body size and von Willebrand factor exocytosis, respectively.

A prevalent focused human antibody response to the influenza hemagglutinin head interface

The paper identifies a focused, protective antibody response targeting a conserved region at the influenza hemagglutinin head interface, showing cross-serotype binding and potential for durable immunity.

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

This study shows that ESRG, a HERV-H-driven lncRNA in human pluripotent stem cells, is not required for maintaining or reprogramming pluripotency.

Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole

Regulation of light harvesting in multimeric and monomeric photosystem II supercomplexes

The paper identifies monomeric and multimeric PSII-LHCII supercomplexes in spinach leaves and shows multimeric forms have higher light-harvesting but lower thermal dissipation capabilities under low-light conditions.

Biosynthesis of β-(1->5)-Galactofuranosyl Chains of Fungal-Type and O-Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus

This study identifies GfsA and GfsC as enzymes responsible for biosynthesis of β-(1→5)-galactofuranosyl residues in Aspergillus fumigatus, showing their roles in cell growth and virulence.

Structural basis for two-way communication between dynein and microtubules

This study investigates the structural basis of two-way communication between dynein and microtubules using NMR and cryo-EM, revealing conformational changes in the MTBD and their implications for dynein movement.

An alternative nisin A resistance mechanism affects virulence in Staphylococcus aureus

This study identifies an alternative nisin A resistance mechanism in S. aureus through pmtR mutation, leading to increased virulence and reduced survival in a mouse model.

Isolation of lactic acid bacteria capable of reducing environmental alkyl and fatty acid hydroperoxides, and the effect of their oral administration on oxidative-stressed nematodes and rats

The paper isolates two lactic acid bacteria capable of reducing hydroperoxides and shows their ability to extend lifespan in nematodes and inhibit lipid peroxidation in rats.