Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control
C. M. Byrne, C. Johnson, J. Orem, F. Okuku, M.-L. Huang, S. Selke, A. Wald, L. Corey, J. T. Schiffer, C. Casper, D. Coombs, S. Gantt
This study finds that HIV-1 co-infection increases oral EBV shedding due to B cell activation and weakened cellular immune control, validated through mathematical modeling.
bioRxiv · Mar 24, 2019 · PreprintPathology