Author

D. Coombs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. M. Byrne· 2 shared J. Scurll· 2 shared L. Abraham· 2 shared M. R. Gold· 2 shared S. Gantt· 2 shared A. C. Marquez· 1 shared A. Wald· 1 shared B. Cai· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

C. M. Byrne

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatial kinetics and immune control of murine cytomegalovirus infection in the salivary glands

C. M. Byrne, A. C. Marquez, B. Cai, D. Coombs, S. Gantt

This study investigates the spatial kinetics and immune control of murine cytomegalovirus infection in salivary glands, identifying immune correlates and constructing mathematical models to understand viral spread and control.

bioRxiv · Feb 22, 2024Microbiology

StormGraph: A graph-based algorithm for quantitative clustering analysis of diverse single-molecule localization microscopy data

J. Scurll, L. Abraham, D. W. Zheng, R. Tafteh, K. Chou, M. R. Gold, D. Coombs

StormGraph is a graph-based algorithm for clustering SMLM data, outperforming existing methods in analyzing heterogeneous datasets and revealing new insights into BCR clustering.

bioRxiv · Oct 20, 2020 · PreprintBiophysics

Diffusion analysis of single particle trajectories in a Bayesian nonparametrics framework

R. Cardim Falcao, D. Coombs

The paper introduces an infinite Hidden Markov Model (iHMM) to infer diffusive states and motion parameters from single particle tracking data without predefining the number of states.

bioRxiv · Jul 16, 2019Biophysics

Arp2/3 complex-driven spatial patterning of the B cell receptor (BCR) enhances immune synapse formation, BCR signaling, and cell activation

M. Bolger-Munro, K. Choi, J. Scurll, L. Abraham, R. Chappell, D. Sheen, M. Dang-Lawson, X. Wu, J. J. Priatel, D. Coombs, J. A. Hammer, M. R. Gold

The paper shows that Arp2/3 complex-driven spatial reorganization of BCR microclusters enhances immune synapse formation, BCR signaling, and B cell activation in response to membrane-bound antigens.

bioRxiv · Apr 30, 2019Immunology

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control

C. M. Byrne, C. Johnson, J. Orem, F. Okuku, M.-L. Huang, S. Selke, A. Wald, L. Corey, J. T. Schiffer, C. Casper, D. Coombs, S. Gantt

This study finds that HIV-1 co-infection increases oral EBV shedding due to B cell activation and weakened cellular immune control, validated through mathematical modeling.

bioRxiv · Mar 24, 2019 · PreprintPathology