Author

C. Casper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Reed· 4 shared A. Gerhardt· 3 shared P. Battisti· 3 shared S. Beaver· 3 shared D. Hanson· 2 shared E. A. Voigt· 2 shared E. Voigt· 2 shared F. Okuku· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersImmunology

S. Reed

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

M. F. Jennewein, M. D. Schultz, S. Beaver, P. Battisti, J. Bakken, D. Hanson, J. Akther, F. Zhou, R. Mohamath, J. Singh, N. Cross, D. N. Kasal, M. Ykema, S. Reed, D. Kalange, , E. A. Voigt

This study compares intranasal and intramuscular delivery of a self-amplifying RNA SARS-CoV-2 vaccine, showing that intranasal delivery induces mucosal immunity and reduces viral transmission.

bioRxiv · Nov 10, 2022 · PreprintImmunology

A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

E. A. Voigt, A. Gerhardt, D. Hanson, P. Battisti, S. Reed, J. Singh, R. Mohamath, M. F. Jennewein, J. Bakken, S. Beaver, C. Press, P. Soon-Shiong, C. J. Paddon, C. B. Fox, C. Casper

This paper develops a self-amplifying RNA vaccine against SARS-CoV-2 with room-temperature stability and strong immune responses in preclinical studies.

bioRxiv · Mar 22, 2022Immunology

Heteologous saRNA-Prime, DNA Dual-Antigen-Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

A. Rice, M. Verma, E. Voigt, P. Battisti, S. Beaver, S. Reed, K. Dinkins, S. Mody, L. Zakin, S. Tanaka, B. Morimoto, W. Higashide, C. A. Olson, E. R. Gabitzsch, J. T. Safrit, , P. Soon-Shiong

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

bioRxiv · Nov 29, 2021 · PreprintImmunology

A Thermostable, Flexible RNA Vaccine Delivery Platform for Pandemic Response

A. Gerhardt, E. Voigt, M. Archer, S. Reed, E. Larson, N. Van Hoeven, R. Kramer, C. Fox, C. Casper

This paper introduces a thermostable RNA vaccine delivery system stable at room temperature for 8+ months and refrigerated for 21+ months, improving vaccine distribution in low-resource settings.

bioRxiv · Feb 1, 2021Bioengineering

Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma

C. Santiago, J. D. Goldman, H. Zhao, A. P. Pankow, F. Okuku, M. W. Schmitt, L. H. Chen, C. A. Hill, C. Casper, W. T. Phipps, J. I. Mullins

This study analyzes KSHV genome variability in Ugandan HIV-associated KS patients, finding high homogeneity within individuals but tumor-specific mutations and inactivations.

PLOS Pathogens · Jan 19, 2021Peer-reviewedMicrobiology

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control

C. M. Byrne, C. Johnson, J. Orem, F. Okuku, M.-L. Huang, S. Selke, A. Wald, L. Corey, J. T. Schiffer, C. Casper, D. Coombs, S. Gantt

This study finds that HIV-1 co-infection increases oral EBV shedding due to B cell activation and weakened cellular immune control, validated through mathematical modeling.

bioRxiv · Mar 24, 2019 · PreprintPathology