Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells
T. B. Reid, C. Godornes, V. L. Campbell, K. J. Laing, L. C. Tantalo, A. Gomez, T. N. Pholsena, N. A. P. Lieberman, T. M. Krause, V. I. Cegielski, L. A. Culver, N. Nguyen, D. Q. Tong, K. L. Hawley, A. L. Greninger, , D. M. Koelle
The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.
bioRxiv · Feb 27, 2024Immunology