J. P. Svensson

This study uses a single-cell method to assess HIV-1 proviral chromatin activation and shows that T cell stimulation differentially activates proviruses based on their chromatin state.

The paper investigates HIV-1 provirus chromatin maturation in primary resting CD4+ T cells, finding that heterochromatin formation reduces proviral activation potential while some cells retain active marks.

The paper identifies that latency reversing agents reactivate less than 5% of latent HIV proviruses and shows distinct chromatin functional states between reactivated and non-reactivated cells.