E. Verdin

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

Viral gene drive spread during herpes simplex virus 1 infection in mice

This study demonstrates that a viral gene drive can spread in vivo during HSV-1 infection in mice by promoting co-infection and recombination.

A ketogenic diet reduces age-induced chronic neuroinflammation in mice

This study shows that a cyclic ketogenic diet reduces neuroinflammation in aging mice by modulating microglial responses to inflammatory stimuli.

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.

Biological characterization of an emergent virus infecting vegetables in diversified production systems: physostegia chlorotic mottle virus

This study characterizes Physostegia chlorotic mottle virus (PhCMoV), identifying its host range, transmission mode, and impact on crops, while mapping its geographic distribution and suggesting management strategies.

SARS-CoV-2 ORF8 limits expression levels of Spike antigen.

This study identifies ORF8 as a SARS-CoV-2 protein that reduces Spike antigen levels on infected cells, thereby limiting antibody recognition and immune evasion.

In-depth Analysis of the Sirtuin 5-regulated Mouse Brain Acylome using Library-free Data-Independent Acquisitions

This study presents a DIA-based workflow to analyze PTMs in mouse brains, identifying SIRT5-regulated malonylation and succinylation sites and their impact on metabolic and neurodegenerative pathways.

Coenzyme A binding sites induce proximal acylation across protein families

The paper identifies that CoA-binding sites promote proximal lysine acylation in mitochondria through computational analysis and experimental validation.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

This study identifies SIRT5 as a proviral factor that interacts with SARS-CoV-2 Nsp14, enhancing viral replication and suggesting it as a therapeutic target.

A Proposed Unified Mitotic Chromosome Architecture

The paper proposes a unified molecular architecture for human Chromosome 10 throughout the mitotic cycle, based on interphase structure and validated by digital PCR.

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin

This study uses a single-cell method to assess HIV-1 proviral chromatin activation and shows that T cell stimulation differentially activates proviruses based on their chromatin state.

Deep Learning Shows Cellular Senescence Is a Barrier to Cancer Development

This study uses deep learning to predict cellular senescence from cell morphology and finds higher senescence rates correlate with lower cancer incidence.

Targeting conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

This study shows that targeting conserved sequences in a viral gene drive prevents resistance evolution in human cytomegalovirus, leading to durable attenuation of viruses.

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

FOXO1 promotes HIV Latency by suppressing ER stress in T cells

This study shows FOXO1 promotes HIV latency by suppressing ER stress in T cells and identifies pathways to selectively reverse quiescence and reduce viral reservoirs.

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

The paper tracks HIV-1 proviral clones over time in polyclonal populations, revealing stable, clone-specific expression patterns and clonal expansion dynamics independent of cell-type or metabolic factors.

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

Viral gene drive in herpesviruses

This study designs a viral gene drive system for herpesviruses, demonstrating its ability to spread engineered traits and replace wildtype populations in cell culture.

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.

Chromatin Functional States Correlate with HIV Latency Reversal in Infected Primary CD4+ T Cells

The paper identifies that latency reversing agents reactivate less than 5% of latent HIV proviruses and shows distinct chromatin functional states between reactivated and non-reactivated cells.

Histone Deacetylase 7 Mediates Tissue-Specific Autoimmunity via Control of Innate Effector Function in Invariant Natural Killer T-Cells

This study shows HDAC7 regulates NKT cell development and function, with its disruption leading to tissue-specific autoimmunity, particularly in hepatobiliary diseases.