Lineage-Specific Epigenomic and Genomic Activation of the Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
J. Pan, T. C. Silva, N. Gull, Q. Yang, J. Plummer, S. Chen, K. Daigo, T. Hamakubo, S. Gery, L.-W. Ding, Y.-Y. Jiang, S.-Y. Hu, L.-Y. Xu, E.-M. Li, Y. Ding, , D.-C. Lin
The paper identifies lineage-specific activation of HNF4A in gastrointestinal adenocarcinomas through epigenomic and genomic analysis, revealing its role in promoting cancer proliferation.
bioRxiv · Oct 21, 2019Cancer Biology