EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma
X. Shi, Y. Zheng, L. Jiang, B. Zhou, W. Yang, L. Li, L. Ding, M. Huang, S. Gery, D.-C. Lin, H. P. Koeffler
This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.
bioRxiv · Jan 15, 2020Cancer Biology