MicrobiologybioRxiv
SyngenicDNA: stealth-based evasion of restriction-modification barriers during bacterial genetic engineering
C. D. Johnston, S. L. Cotton, S. R. Rittling…·K. P. Lemon
The paper introduces SyngenicDNA and SyMPL tools to bypass restriction-modification barriers in bacteria, achieving >100,000-fold improvement in transformation efficiency for Staphylococcus aureus.
DOI 10.1073/pnas.1820256116