BiochemistrybioRxivPreprint
Structural models of full-length JAK2 kinase
P. Ayaz, H. Hammaren, J. Raivola…·D. Shaw
This study presents structural models of full-length JAK2 in active and inactive forms, revealing how the V617F mutation disrupts autoinhibition and promotes constitutive activity.
DOI 10.1101/727727