Y. Shan

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

Simplicity: web-based visualization and analysis of high-throughput cancer cell line screens

Simplicity provides a web-based tool for visualizing and analyzing high-throughput cancer cell line screens, enabling recalculation of summary statistics at user-defined drug concentrations.

Ion selectivity and activation mechanism for kalium channelrhodopsins

This study reveals the ion selectivity and activation mechanism of kalium channelrhodopsins through cryo-EM structures of various variants.

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

This study identifies the molecular mechanism of voltage sensing in hEag2 channels, revealing how the S4-S5 linker and potassium ion contribute to delayed rectifier properties and the Cole-Moore effect.

Mechanism of physical force induced human slack channel desensitization

This study identifies hSlack as a voltage-dependent physical force-induced desensitization potassium channel, showing structural and functional changes mediated by pore lipids.

Cryo-EM structures of kalium channelrhodopsins KCRs

The paper reports cryo-EM structures of HcKCR1 and HcKCR2, revealing their conducting and non-conducting states and mechanisms of potassium selectivity and light-gating.

The trifecta of disease avoidance, silique shattering resistance and flowering period elongation achieved by the BnaIDA editing in Brassica napus

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

The structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in plexin regulation

This study uses molecular dynamics simulations to show how RND1 and RhoD GTPases differentially affect plexin dimerization through distinct membrane interactions.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

How does a small molecule bind at a cryptic binding site?

This study uses molecular dynamics simulations and free energy perturbation to identify and characterize small molecule binding at cryptic sites in protein-protein interactions.

A deep-sea sulfate reducing bacterium directs the formation of zero-valent sulfur via sulfide oxidation

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

Cultivation and characterization of a novel clade of deep-sea Chloroflexi: providing a glimpse of the phylum Chloroflexi involved in sulfur cycling

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

Characterization of the first cultured free-living representative of Candidatus Izimaplasma uncovers its unique biology

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

Beware of asymptomatic transmission: Study on 2019-nCoV prevention and control measures based on extended SEIR model

This study uses an extended SEIR model to evaluate the impact of prevention measures on 2019-nCoV spread, highlighting the importance of addressing asymptomatic transmission.

High-throughput isolation and sorting of gut microbes reduce biases of traditional cultivation strategies

This study develops a microfluidic platform to isolate and sort gut microbes, increasing richness and rare taxa representation compared to traditional methods.

Structural models of full-length JAK2 kinase

This study presents structural models of full-length JAK2 in active and inactive forms, revealing how the V617F mutation disrupts autoinhibition and promotes constitutive activity.