Structural basis of recruitment of RBM39 to DCAF15 by a sulfonamide molecular glue E7820
X. Du, O. A. Volkov, R. Czerwinski, H. Tan, C. Huerta, E. Morton, J. Rizzi, P. Wehn, R. Xu, D. Nijhawan, E. Wallace
The paper investigates how E7820 recruits RBM39 to the DCAF15 E3 ligase complex through structural and kinetic analysis, revealing its mechanism as a molecular glue.
bioRxiv · Sep 5, 2019Biophysics