Author

J. S. Fraser

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Biophysics· 18 Biochemistry· 7 Bioengineering· 2 Cancer Biology· 1 Immunology· 1 Microbiology· 1

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Approach:experimental assay· 19 Research Focus:protein folding & dynamics· 16 Assay:structural biology· 13 Approach:statistical model· 10 Assay:protein structure· 8 Approach:deep learning· 6 Organism:mouse· 5 Research Focus:protein structure prediction· 5

Frequent Co-Authors

M. C. Thompson· 9 shared A. M. Wolff· 5 shared G. J. Correy· 5 shared H. van den Bedem· 5 shared I. D. Young· 5 shared B. A. Barad· 4 shared J. T. Biel· 4 shared L. Liu· 4 shared

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9 shared papersBiophysics

M. C. Thompson

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31 papers

Recent·Most cited

BiophysicsbioRxivOct 17, 2016

Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

J. T. Biel, M. C. Thompson, C. N. Cunningham…·J. S. Fraser

This study shows that increasing flexibility in designed proteins can help escape local minima during evolution, using redesigned ubiquitin variants with improved binding affinity to USP7.

DOI 10.1016/j.str.2017.03.009

experimental assayprotein folding & dynamics

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