Author

C. N. Cunningham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Organism:Drosophila· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. Rutter· 3 shared A. A. Cluntun· 2 shared J. A. Berg· 2 shared J. M. Winter· 2 shared Y. Ouyang· 2 shared A. G. Toshniwal· 1 shared A. J. Bott· 1 shared A. Letai· 1 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCancer Biology

J. Rutter

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

Y. Ouyang, C. N. Cunningham, J. A. Berg, A. G. Toshniwal, C. E. Hughes, J. G. Van Vranken, M.-Y. Jeong, A. A. Cluntun, G. Lam, J. M. Winter, E. Akdogan, K. K. Dove, S. P. Gygi, C. D. Dunn, D. R. Winge, J. Rutter

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

bioRxiv · Oct 25, 2022Cell Biology

Mitochondrial pyruvate supports lymphoma proliferation by fueling a non-canonical glutamine metabolism pathway

P. Wei, A. J. Bott, A. A. Cluntun, J. T. Morgan, C. N. Cunningham, J. C. Schell, Y. Ouyang, S. B. Ficarro, J. A. Marto, N. N. Danial, R. J. DeBerardinis, J. Rutter

This study identifies a non-canonical glutamine metabolism pathway in DLBCLs where mitochondrial pyruvate supports glutaminolysis and proliferation, particularly in solid extracellular matrix environments.

bioRxiv · Aug 26, 2021 · PreprintCancer Biology

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

Flexibility and design: conformational heterogeneity along the evolutionary trajectory of a redesigned ubiquitin

J. T. Biel, M. C. Thompson, C. N. Cunningham, J. E. Corn, J. S. Fraser

This study shows that increasing flexibility in designed proteins can help escape local minima during evolution, using redesigned ubiquitin variants with improved binding affinity to USP7.

bioRxiv · Oct 17, 2016Biophysics